Orangguerra

Extremely large orangutan-like demonic enforcers who Dante and Lucia must defeat, which appear to be relatives to Msira demons. It is first encountered by Dante in mission 3 (where it serves as the level boss), and only once by Lucia in mission 4. With its thick skin it is hard to harm this monster with your starting weapons. It uses its large arms to strike at enemies and it can latch onto the ceiling and climb to another area to perform an attack. They will try to smash their enemies with their weight or throw you. Though this is hard to have happen, if you attack its arms, you will cut one arm off, making the beast much easier to fight.

Strategy
A good way to get rid of him is shooting at him from a distance, and constantly avoiding his jumps. Also, you might wanna stay away from him when he hangs on the ceiling, to avoid his stomping. When the Msiras start appearing, focus on the Orangguerra to finish him quickly.

Trivia

 * The word guerra is a Spanish term meaning war. The Oranguerra term could mean "war monkey" though Arius used these monsters as a part of a demon army to serve his industrial empire Uroboros.