User blog comment:QueenShebaPunch/DmC: A Reboot or Alternate Universe?/@comment-976055-20121023043842

It's not part of the classic series, but starts its own continuity.

The DmC: Devil May Cry Knowledge Primer I put together will be able to answer pretty much any questions you might have about it n.n

Happy demon-hunting in the classic series though. They're a blast, although DMC2 might leave something lacking...it was the odd duck of the bunch :p