User blog comment:Metaron Isard/Can Dante Drown/@comment-4720688-20120524051452

Huh, that's something I never actually thought of... I'm pretty sure decapitation and total explosive disintegration will do the trick, but drowning...

I think he can hold his breath for a hella long time, and he's probably not subject to the normal rules of no-oxygen-for-x-time-equals-brain-damage, but he probably CAN asphyxiate. It would just take longer.