Eva

"Hide that name. Blind yourself to it and run away"

-Eva to Dante, as a child, in the novel.

Eva was the human wife of Sparda and mother of the twins Vergil and Dante. Little is known about Eva. She appears only as a photo on Dante's desk and as a voice in a flashback in the first Devil May Cry game.

Story
For Dante and Vergil's 8th birthday, she gave each of the boys one half of Sparda's Perfect Amulet. Afterwards, she was killed in a demon attack ordered by Mundus. She hid Dante underneath two stones and told him never to come out, no matter what. She gave her life for her sons. It is unclear where Vergil was at this time. Eva's death is most likely the event that shaped the paths Dante and Vergil took, causing Dante to fight demons and Vergil to search for Force Edge.

After Dante grew to adulthood, Trish was made by Mundus to look like Eva in order to manipulate Dante. Dante's lingering feelings for Eva are most clearly seen when Trish is saved by Dante despite her already betraying him.

Bayonetta
In the description for the Bracelet of Time in Bayonetta, Eva is described as a historical witch who entered into contract with a legendary dark knight".

DmC: Devil May Cry
In the relaunch of Devil May Cry, DmC: Devil May Cry, Eva is an angel. She fell in love with the demon Sparda and gave birth to twin sons, and  before Mundus killed her and imprisoned Sparda.

Background
Eva is an alternate spelling for Eve, who in the Bible is said to have been the first woman created by God. Eve is infamous for having been tempted by the serpent to eat the Forbidden Fruit, which led to Adam and Eve being exiled from the Garden of Eden as punishment for succumbing to temptation. In some versions, she is a replacement for Adam after God's previous creation, Lilith, who abandoned Adam and became a demon.

Trivia
Eva's original death was different from the Devil May Cry 3 manga's depiction. In the novel, she was torn to pieces by vengeful demons right in front of Dante's eyes and Vergil was kidnapped by the demons, yet in the manga her death was altered slightly in that she told Dante to hide before dying in the demon's attack and Vergil's whereabouts are not explained.