Argosax

Argosax the Chaos was a powerful demonic king who once ruled the Demon World, and was infrequently worshiped by the people of Dumary Island. However, he was recognized as evil, and was eventually defeated by Sparda and the Vie de Marii. He serves as the boss of Mission 18, the final mission of Dante's scenario in Devil May Cry 2.

In Devil May Cry 2, Arius tries to obtain the Arcana in order to release Argosax, take his power, and become a god. The Arcana are four holy relics used to seal Argosax, and by uniting them at the solar eclipse, a gate to the Demon World will open.
 * The Arcana Medaglia (lit. "Occult Medal" in Italian) is found by Lucia in a museum during the prologue. After finding it, she is attacked by several Puias and is rescued by Dante.
 * The Arcana Spada (lit. "Occult Sword" in Italian) is guarded by Tartarussian in the clock tower, and is found by Lucia after she defeats him.
 * The Arcana Calice (lit. "Occult Goblet" in Italian) is guarded by Plutonian in the underground ruin, and is found by Lucia after she defeats him.
 * The Arcana Bastone (lit. "Occult Rod" in Italian) belongs to Matier, and is given to Lucia after she obtains the Spada.

Though Dante manages to interfere with Arius' ritual by replacing the Medaglia with his own double-sided coin, the doorway is still partially opened, and Arius absorbs part of Argosax's power. Because the door is unstable, whoever enters may not be able to return, so Lucia demands to go, claiming she is expendable. However, Dante puts the decision to his coin, and after winning the coin toss, goes in, just like his father once did.

Inside the portal, Dante finds Argosax in its first form, a hideous pile of flesh composed of pieces of Phantom, Griffon, Orangguerra, Jokatgulm, Nefasturris, and Furiataurus. After slaying each piece, a stalk bearing an egg extends from the mass, and Argosax's true form, The Despair Embodied hatches from it.

As The Despair Embodied, Argosax appears as an androgynous, horned, angelic being composed of fire, able to change sexes at will. While in its female form, it attacks with a whip, while in its male form, it wields a sword. The Despair Embodied is able to teleport around the battlefield, or fly into the air and shower Dante with a rain of fiery feathers. However, even in this awesome form, Argosax is still no match for Dante, and is destroyed. Afterwards, Dante rides off on a motorcycle, presumably escaping the Demon World through another doorway.