Human

Humans are the beings native to the human world and they are considered its dominant species, dispite their weak nature. While their nature grants them no magical powers, they possess the potential to love and live for others, this trait is often called the "soul". Because of their lack of magic and general inferiority in regards to strength, humans are usually no match for demons, even lesser ones. However, certain humans who have trained for years and who possess mighty weapons, such as Lady or the Order of the Sword, are able to combat and defeat demons. Other humans attempt to overcome this weakness by obtaining demonic power through complex rituals; Arius (who summoned Argosax with the Arcana in Devil May Cry 2), Arkham (who took the Sparda in Devil May Cry 3), and most of the Order of the Sword (who performed the Ascension Ceremony to become artificial demon-human hybrids in Devil May Cry 4) took this approach. These attempts are generally part of a plan to conquer the world, and have had Dante say that humans can occasionally be more evil than demons.

Despite this severe difference in strength, and the general enmity between the two species, humans and demons can fall in love and mate, producing natural human-demon hybrids. Sparda and Eva are the most prominent example of this, though Bradley and Angelina Hagel go through a similar romance in Devil May Cry: The Animated Series. The human-demon hybrid Dante and the artificial demon Trish also seem to have fallen in love, at least temporarily.

While humans generally don't have any magical powers by themselves, Arius was able to manipulate demonic energy, while being completely human. It can be speculated that his powers were more of an alchemist, than a magician, though there is no direct reference to it.