User blog comment:Metaron Isard/Can Dante Drown/@comment-68.197.222.142-20120601213848

An interesting question as most video game characters don't actually prove they have to breathe (and the Rule of Cool usually exaggerates their lung capacity even if they're supposed to be human). The only help I can offer is that in Dante's fights with Vergil and Nero he has been shown breathing heavily afterwards, so even if he can hold his breath super-long, he needs oxygen to feed his muscles (or it's just instinctive).