Gilgamesh is a titanic demon, similar to an insect, with four legs and a elongated body similar to a cockroach, though with disproportionately long legs. It has two tendrils which extend from its sides which it uses to create lightning like blasts.
It is not in fact a demon from the underworld in its own right, but roots of the Qliphoth encased in the supernatural metal from which it derives its name.
Gilgamesh is first encountered by V after he slays Nidhogg. V initially intends to avoid Gilgamesh as he lacks the strength to face the behemoth head on, but it notices him and opens fire. Gilgamesh's energy blasts destroy the ground under V's feet, sending him into the sewers. He eventually arrives at the bottom of a shipyard, Gilgamesh still pursuing him as it smashes its legs through the ceiling in an attempt to crush him.
Around this time, Nero sees Gilgamesh heading through the shipyards and decides to attack the demon, deeming it too dangerous to be left wandering. Through collaborative efforts with V, Nero defeats the demon. A recovered chunk of metal from the creature is then used by Nico to fabricate a new Devil Breaker.
Nico's Enemy Report - Gilgamesh
- Gilgamesh is a kind of metal that can be mined from the bedrock of the underworld. Fuse it with demon flesh, and you've got armor harder than steel.
- That's what we got here. Seems somebody decided to fuse the roots of the Qliphoth with a batch of Gilgamesh, and before you know it there's a three-story metal demon walkin' around.
- The really rad thing about Gilgamesh is that it can create shockwaves outta thin air. That's how this varmint was blowin' things up from a distance—and it means runnin' don't do you no good.
- If you want to kill somethin' like this, you gotta get up close 'n' personal.
Gilgamesh will launch lightning blasts from its tendrils throughout the battle, but these are really only a problem when attacking the central node. Use of the Gerbera Devil Breaker will allow the player to repel or dodge these attacks as they see fit, but failing that, moving behind the node can prove effective at avoiding the fire.
- In Devil May Cry 4, Dante obtains a Devil Arm known as Gilgamesh. It is revealed in Devil May Cry 5 that Gilgamesh is actually the demon metal that the Devil Arm was made from.
- Gilgamesh is one of the bosses not present in the Bloody Palace.